A sensitive method for determination of allergenic fragrance terpene hydroperoxides using liquid chromatography coupled with tandem mass spectrometry
Identifieur interne : 001103 ( Main/Exploration ); précédent : 001102; suivant : 001104A sensitive method for determination of allergenic fragrance terpene hydroperoxides using liquid chromatography coupled with tandem mass spectrometry
Auteurs : Johanna Rudb Ck [Suède] ; Nurul Islam [Suède] ; Ulrika Nilsson [Suède] ; Ann-Therese Karlberg [Suède]Source :
- Journal of Separation Science [ 1615-9306 ] ; 2013-04.
Descripteurs français
- Pascal (Inist)
- Allergène, Analyse chimique, Analyse qualitative, Autooxydation, Bigarade, Chromatographie HPLC, Citrus aurantium, Citrus sinensis, Dermatite de contact, Electrospray, Huile essentielle, Hydroperoxyde organique, LC MS MS, Linalol, Linalol acétate, Monoterpène, Méthode couplée, Orange douce, Parfum, Produit réaction, Spectrométrie masse tandem, Terpénoïde, p-Mentha-1,8-diène, p-Menthane dérivé.
- Wicri :
- topic : Analyse qualitative, Huile essentielle.
English descriptors
- KwdEn :
- 1,8-p-Menthadiene, Allergen, Autoxidation, Bitter orange, Chemical analysis, Citrus aurantium, Citrus sinensis, Contact dermatitis, Coupled method, Electrospray, Essential oil, HPLC chromatography, Monoterpene, Organic hydroperoxide, Perfume, Qualitative analysis, Reaction product, Sweet orange, Tandem mass spectrometry, Terpenoid.
Abstract
Different compositions of monoterpenes are utilized for their pleasant scent in cosmetics and perfumes. However, the most commonly used fragrance terpenes easily oxidize upon contact with air, forming strongly skin‐sensitizing hydroperoxides. Due to their thermolability and low UV absorbance, detection methods for hydroperoxides are scarce. For the first time, a simple and sensitive method using LC/ESI‐MS/MS was developed to quantitatively determine hydroperoxides from the common fragrance compounds linalool, linalyl acetate, and limonene. The method was applied to autoxidized petitgrain oil and sweet orange oil. A separation was accomplished using a C3 column. The method LOD for the investigated hydroperoxides in the essential oils was below 0.3 μg/mL, corresponding to 0.3 ppm. For prevention purposes and according to EU regulations, concentrations in cosmetics exceeding 100 ppm in “rinse‐off” and 10 ppm in “stay‐on” products of linalool and limonene must be labeled. However, the products may still contain allergens, such as hydroperoxides, formed by oxidative degradation of their parent terpenes. The sensitivity and selectivity of the presented LC/MS/MS method enables detection of hydroperoxides from the fragrance terpenes linalool, linalyl acetate, and limonene. However, for routine measurements, the method requires further validation.
Url:
DOI: 10.1002/jssc.201200855
Affiliations:
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Le document en format XML
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Science</title><idno type="ISSN">1615-9306</idno><idno type="eISSN">1615-9314</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><date type="published" when="2013-04">2013-04</date><biblScope unit="volume">36</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1370">1370</biblScope><biblScope unit="page" to="1378">1378</biblScope></imprint><idno type="ISSN">1615-9306</idno></series><idno type="istex">E31F97975945C370F448A363AE230A1E514B4CA4</idno><idno type="DOI">10.1002/jssc.201200855</idno><idno type="ArticleID">JSSC3226</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1615-9306</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1,8-p-Menthadiene</term><term>Allergen</term><term>Autoxidation</term><term>Bitter orange</term><term>Chemical analysis</term><term>Citrus aurantium</term><term>Citrus sinensis</term><term>Contact dermatitis</term><term>Coupled method</term><term>Electrospray</term><term>Essential oil</term><term>HPLC chromatography</term><term>Monoterpene</term><term>Organic hydroperoxide</term><term>Perfume</term><term>Qualitative analysis</term><term>Reaction product</term><term>Sweet orange</term><term>Tandem mass spectrometry</term><term>Terpenoid</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Allergène</term><term>Analyse chimique</term><term>Analyse qualitative</term><term>Autooxydation</term><term>Bigarade</term><term>Chromatographie HPLC</term><term>Citrus aurantium</term><term>Citrus sinensis</term><term>Dermatite de contact</term><term>Electrospray</term><term>Huile essentielle</term><term>Hydroperoxyde organique</term><term>LC MS MS</term><term>Linalol</term><term>Linalol acétate</term><term>Monoterpène</term><term>Méthode couplée</term><term>Orange douce</term><term>Parfum</term><term>Produit réaction</term><term>Spectrométrie masse tandem</term><term>Terpénoïde</term><term>p-Mentha-1,8-diène</term><term>p-Menthane dérivé</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Analyse qualitative</term><term>Huile essentielle</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Different compositions of monoterpenes are utilized for their pleasant scent in cosmetics and perfumes. However, the most commonly used fragrance terpenes easily oxidize upon contact with air, forming strongly skin‐sensitizing hydroperoxides. Due to their thermolability and low UV absorbance, detection methods for hydroperoxides are scarce. For the first time, a simple and sensitive method using LC/ESI‐MS/MS was developed to quantitatively determine hydroperoxides from the common fragrance compounds linalool, linalyl acetate, and limonene. The method was applied to autoxidized petitgrain oil and sweet orange oil. A separation was accomplished using a C3 column. The method LOD for the investigated hydroperoxides in the essential oils was below 0.3 μg/mL, corresponding to 0.3 ppm. For prevention purposes and according to EU regulations, concentrations in cosmetics exceeding 100 ppm in “rinse‐off” and 10 ppm in “stay‐on” products of linalool and limonene must be labeled. However, the products may still contain allergens, such as hydroperoxides, formed by oxidative degradation of their parent terpenes. The sensitivity and selectivity of the presented LC/MS/MS method enables detection of hydroperoxides from the fragrance terpenes linalool, linalyl acetate, and limonene. However, for routine measurements, the method requires further validation.</div></front></TEI><affiliations><list><country><li>Suède</li></country><region><li>Svealand</li></region><settlement><li>Stockholm</li></settlement><orgName><li>Université de Stockholm</li></orgName></list><tree><country name="Suède"><noRegion><name sortKey="Rudb Ck, Johanna" sort="Rudb Ck, Johanna" uniqKey="Rudb Ck J" first="Johanna" last="Rudb Ck">Johanna Rudb Ck</name></noRegion><name sortKey="Islam, Nurul" sort="Islam, Nurul" uniqKey="Islam N" first="Nurul" last="Islam">Nurul Islam</name><name sortKey="Karlberg, Ann Herese" sort="Karlberg, Ann Herese" uniqKey="Karlberg A" first="Ann-Therese" last="Karlberg">Ann-Therese Karlberg</name><name sortKey="Karlberg, Ann Herese" sort="Karlberg, Ann Herese" uniqKey="Karlberg A" first="Ann-Therese" last="Karlberg">Ann-Therese Karlberg</name><name sortKey="Karlberg, Ann Herese" sort="Karlberg, Ann Herese" uniqKey="Karlberg A" first="Ann-Therese" last="Karlberg">Ann-Therese Karlberg</name><name sortKey="Nilsson, Ulrika" sort="Nilsson, Ulrika" uniqKey="Nilsson U" first="Ulrika" last="Nilsson">Ulrika Nilsson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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